Metabolic acidosis is a term used to describe the buildup of excessive amounts of acid in the body’s various fluids. In some cases, this buildup stems from excessive acid production inside the body; in other cases, it stems from the kidneys’ inability to eliminate sufficient amounts of acid from the bloodstream. Whatever the underlying cause, unchecked metabolic acidosis can kill an affected individual. People who use/abuse the illegal street drug methamphetamine can develop metabolic acidosis during the course of a drug overdose. The condition arises as an end result of an unsustainable methamphetamine-related increase in body temperature.